Poor sleep may point to onset of Alzheimer’s disease: study

While some of these relationships were strong when looking at everyone as a group, not everyone with sleep problems has abnormalities in their spinal fluid. There was no link between biological markers in spinal fluid and obstructive sleep apnea.

By: PTI | New York | Published:July 6, 2017 5:53 pm
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Poor, disrupted sleep may indicate the risk of developing Alzheimer’s disease in people who are otherwise healthy, a study warns. Researchers from University of Wisconsin-Madison in the US found that people who reported worse sleep quality, more sleep problems and daytime sleepiness had more biological markers for Alzheimer’s disease in their spinal fluid than people who did not have sleep problems. Those biological markers included signs of the proteins amyloid and tau and brain cell damage and inflammation.

“It’s important to identify modifiable risk factors for Alzheimer’s given that estimates suggest that delaying the onset of Alzheimer’s disease in people by a mere five years could reduce the number of cases we see in the next 30 years by 5.7 million,” said Barbara B Bendlin, PhD student at University of Wisconsin-Madison.

While some of these relationships were strong when looking at everyone as a group, not everyone with sleep problems has abnormalities in their spinal fluid.

There was no link between biological markers in the spinal fluid and obstructive sleep apnea, researchers said.

“It is still unclear if sleep may affect the development of the disease or if the disease affects the quality of sleep,” Bendlin said.

Researchers recruited 101 people with an average age of 63 years who had normal thinking and memory skills but who were considered at risk of developing Alzheimer’s.

They either had a parent with the disease or were a carrier of a gene that increases the risk for Alzheimer’s disease called apolipoprotein E or APOE.

Participants were surveyed about sleep quality. They also provided spinal fluid samples that were tested for biological markers of Alzheimer’s disease.

The study was published in the journal Neurology.

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    Andy Kadir-Buxton
    Jul 8, 2017 at 11:36 am
    Sleep experts say that most mental illness is due to poor, or little, sleep. To get the sleep you get at the coast when the wind blows in from the sea just heat salt water in an oil burner overnight. In just five nights insomnia is cured, and this takes with it all symptoms of mental illness. Sound too dangerous? Then heat the salt water during the day to simulate a walk by the sea side. If the reason you wake up is to go to the toilet then ever increasing lengths of holds in pelvic floor exercises will help.
    Reply