• Associate Sponsor

Now a therapy that helps you lose weight without much effort

Researchers have developed a targeted approach to override the "energy saving" mode and allow muscle to burn more energy,

By: Indo-Asian News Service | Washington | Updated: February 23, 2015 12:44 pm
weight-loss-main Researchers have developed a targeted approach to override the “energy saving” mode and allow muscle to burn more energy, (Source: Thinkstock Images)

Researchers have developed a targeted approach to override the “energy saving” mode and allow muscle to burn more energy, even during low to moderate exercise.

(Also read: ‘Warm’ workout key to weight loss)

The new findings may provide the basis of a therapy that could help people to overcome the body’s natural resistance to weight loss.

“This study shows for the first time that this energy efficiency can be manipulated in a clinically translatable way,” said Denice Hodgson-Zingman from the University of Iowa and co-author of the study.

“While such an approach would not replace the need for a healthy diet or exercise, it could jump start the process of weight loss by overcoming the initial hurdles imposed by our energy-efficient physiology,” Denice noted.

(Also read: Check your weight once a week to lose fat: Study)

An earlier study found that a protein called ATP-sensitive potassium (KATP) channel is a powerful modulator of energy efficiency in skeletal muscle even during low-intensity activity.

Now, the team has shown that altering the activity of the KATP protein causes skeletal muscles to become less efficient and burn more calories.

For the study, the team made a compound called a vivo-morpholino, which suppresses production of KATP.

Injecting this compound into the thigh muscles of mice produced a local loss of the protein but did not affect the protein in other organs or even in neighbouring skeletal muscles.

(Also read: Eat berries to lose weight)

The injected muscles burned more calories than untreated muscle without significantly affecting the muscle’s ability to tolerate exercise.

“By making skeletal muscles less energy efficient, they burn more calories, even while doing normal daily activities,” said Leonid Zingman from the University of Iowa and co-author.

“With this intervention, the benefits of exercise in burning calories could be accessible to a broader range of people by making the calorie burning effects of skeletal muscle greater even at low levels of activity that most people would be able to undertake,” Zingman said.

The study appeared in the journal Molecular Therapy.

For all the latest Lifestyle News, download Indian Express App

  1. H
    Feb 23, 2015 at 4:58 pm
    Trouble Spot Training Review I came across Trouble Spot Training, which is supposed to be a fitness and nutrition system that helps you tackle trouble spots like your arms, butt, abs, and thighs. Most of us know that tackling these trouble spots is very hard to do, so how can this system help us finally get the results we are looking for? Does it actually deliver on its promise?
    1. J
      Feb 23, 2015 at 9:15 pm
      You don’t know me but my name is Elisa and I bought The 3 Week Diet one month ago. I want to share my weight loss story with you, Brian. Since having my first child, I've been carrying around an extra 30 pounds. I've tried many diets and couldn't make anything work. Your diet just made sense and showed me that everything I was doing was wrong and a waste of my time. The 3 Week Diet plan was so refreshing and so simple to follow. I did everything you said and lost 23 pounds in first three weeks. I’m now starting the diet again from the start to lose the 7 pounds more. You have changed my life, and I am incredibly thankful. I advise you that the product :
      1. J
        Feb 23, 2015 at 9:16 pm