Scientists have discovered the three-dimensional structure of the protein Parkin,a finding which may provide new ways to develop drugs to slow the progression of Parkinson’s disease.
Researchers from McGill University worked in collaboration with teams led by Dr Edward A Fon at the Montreal Neurological Institute and Hospital – The Neuro,and Dr Kalle Gehring in the Department of Biochemistry at the Faculty of Medicine.
Mutations in Parkin cause a rare hereditary form of Parkinson’s disease and are likely to also be involved in more commonly occurring forms of Parkinson’s disease.
The Parkin protein protects neurons from cell death due to an accumulation of defective mitochondria. Mitochondria are the batteries in cells,providing the power for cell functions.
This new knowledge of Parkin’s structure has allowed the scientists to design mutations in Parkin that make it better at recognising damaged mitochondria and therefore possibly provide better protection for nerve cells.
“The majority of Parkinson’s patients suffer from a sporadic form of the disease that occurs from a complex interplay of genetic and environmental factors which are still
not fully understood,” said Fon,neurologist at The Neuro and head of the McGill Parkinson Programme.
“A minority of patients have genetic mutations in genes such as Parkin that cause the disease. Although there are differences between the genetic and sporadic forms,there is good reason to believe that understanding one will inform us about the other.
“It’s known that toxins that poison mitochondria can lead to Parkinson’s-like symptoms in humans and animals. Recently,Parkin was shown to be a key player in the cell’s system for identifying and removing damaged mitochondria,” Fon said.
Gehring likens Parkin to a watchdog for damaged mitochondria.
“Our structural studies show that Parkin is normally kept in check by a part of the protein that acts as a leash to restrict Parkin activity. When we made mutations in this
specific ‘leash’ region in the protein,we found that Parkin recognised damaged mitochondria more quickly,” Gehring said.
“If we can reproduce this response with a drug rather than mutations,we might be able to slow the progression of disease in Parkinson’s patients,” Gehring added.
The research will be published in the journal Science.