Saturday, Nov 22, 2014

Nanoparticles cause cancer cells to self-destruct

Press Trust of India | London | Posted: April 4, 2014 12:53 pm | Updated: April 4, 2014 1:03 pm

Using magnetically controlled nanoparticles to force tumour cells to “self-destruct” sounds like science fiction, but could be a part of future cancer treatment, according to new research.

“The clever thing about the technique is that we can target selected cells without harming surrounding tissue. There are many ways to kill cells, but this method is contained and remote-controlled,” said Professor Erik Renstrom from Lund University in Sweden.

The point of the new technique is that it is much more targeted than trying to kill cancer cells with techniques such as chemotherapy.

“Chemotherapy can also affect healthy cells in the body, and it therefore has serious side-effects. Radiotherapy can also affect healthy tissue around the tumour. Our technique, on the other hand, is able to attack only the tumour cells,” said Enming Zhang, one of the first authors of the study.

The technique involves getting the nanoparticles into a tumour cell, where they bind to lysosomes, the units in the cell that perform ‘cleaning patrols’.

The lysosomes have the ability to break down foreign substances that have entered a cell. They can also break down the entire cell through a process known as “controlled cell death,” a type of destruction where damaged cells dissolve themselves.

Researchers used nanoparticles of iron oxide that have been treated with a special form of magnetism. Once the particles are inside the cancer cells, the cells are exposed to a magnetic field, and the nanoparticles begin to rotate in a way that causes the lysosomes to start destroying the cells.

The research group is not the first to try and treat cancer using supermagnetic nanoparticles. However, previous attempts have focused on using the magnetic field to create heat that kills the cancer cells.

The problem with this is that the heat can cause inflammation that risks harming surrounding, healthy tissue.

The new method, on the other hand, in which the rotation of the magnetic nanoparticles can be controlled, only affects the tumour cells that the nanoparticles have entered.

The new technique is primarily intended for cancer treatment, but according to researchers there may be other areas of application.

One example is autoimmune diseases such as type 1 diabetes, in which the immune system attacks the body’s own insulin production.

The study was published in the journal ACS Nano.

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