A bacterial protein found in common house dust may worsen allergic responses of people to indoor allergens,according to a new research.
The finding is the first to document the presence of the protein flagellin in house dust,bolstering the link between allergic asthma and the environment.
“Most people with asthma have allergic asthma,resulting largely from allergic responses to inhaled substances,” said researcher Donald Cook.
Scientists from the NIH’s National Institute of Environmental Health Sciences (NIEHS) and Duke University Medical Centercarried out the study to identify environmental factors that amplify the allergic responses.
“Although flagellin is not an allergen,it can boost allergic responses to true allergens,” Cook said in a statement.
After inhaling house dust,mice that were able to respond to flagellin displayed all of the common symptoms of allergic asthma,including more mucous production,airway obstruction,and airway inflammation.
However,mice lacking a gene that detects the presence of flagellin had reduced levels of these symptoms.
“More work will be required to confirm our conclusions,but it’s possible that cleaning can reduce the amount of house dust in general,and flagellated bacteria in particular,to reduce the incidence of allergic asthma,” Cook said.
Researchers also determined that people with asthma have higher levels of antibodies against flagellin in their blood than do non-asthmatic subjects,which provides more evidence of a link between environmental factors and allergic asthma in humans.
“More than 20 million Americans have asthma,with 4,000 deaths from the disease occurring each year,” said Darryl Zeldin,NIEHS scientific director and study co-author.
“All of these data suggest that flagellin in common house dust can promote allergic asthma by priming allergic responses to common indoor allergens,” he said.
The study findings are published in the journal ‘Nature Medicine’.