Move over, botox! Researchers have developed a non-invasive technique that harnesses pulsed electric fields to generate new skin tissue growth and it has the potential to revolutionize treatment of degenerative skin diseases.
Botulinum toxin, commonly known as botox, which smoothes lines and wrinkles to rejuvenate the ageing face has been the number one nonsurgical procedure in the US since 2000.
But injections of this toxic bacterium are only a temporary solution and carry many risks, some neurological, said researchers.
A team of Tel Aviv University and Harvard Medical School researchers has now devised a non-invasive tissue stimulation technique which utilises microsecond-pulsed, high-voltage, non-thermal electric fields, to produce scarless skin rejuvenation.
The technique may revolutionise the treatment of degenerative skin diseases, researchers said. “Pulsed electrical field technology has many advantages, which have already proved effective – for example, in food preservation, tumour removal, and wound disinfection,” said Dr Alexander Golberg of TAU’s Porter School of Environmental Studies.
“Our new application may jumpstart the secretion of new collagen and capillaries in problematic skin areas.
“Considering that, in the modern era of ageing populations and climate change, degenerative skin diseases affect one in three adults over the age of 60, this has the potential to be an healthcare gamechanger,” he said.
Current therapies to rejuvenate skin use various physical and chemical methods to affect cells and the extracellular matrix, but they induce unsightly scarring.
Pulsed electric fields, however, affect only the cell membrane itself, preserving the extracellular matrix architecture and releasing multiple growth factors to spark new cell and tissue growth.
By inducing nanoscale defects on the cell membranes, electric fields cause the death of a small number of cells in affected areas. The released growth factors increase the metabolism of the remaining cells, generating new tissue.
“We have identified in rats the specific pulsed electric field parameters that lead to prominent proliferation of the epidermis, formation of microvasculature, and secretion of new collagen at treated areas without scarring,” said Golberg.
“Our results suggest that pulsed electric fields can improve skin function and potentially serve as a novel non-invasive skin therapy for multiple degenerative skin diseases,” he said.
The researchers are currently developing a low-cost device for use in clinical trials in order to test the safety and efficacy of the technology in humans.