• Associate Sponsor

Innate immune cells show promise against HIV: NARI

The findings of three separate studies could be a gamechanger in treatment of HIV-positive people.

Written by Anuradha Mascarenhas | Pune | Published: May 19, 2015 3:41 am
NARI, National AIDS Research Institute, HIV, AIDS, AIIMS, HIV antigen, pune news, city news, local news, pune newsline, maharashtra news, Indian Express Researchers was conducted at NARI, in collaboration with the All India Institute of Medical Sciences (AIIMS), New Delhi and Bangalore-based Jawaharlal Nehru Institute of Advanced Research.

A new study at the National AIDS Research Institute (NARI) shows for the first time that cells responsible for the body’s first line of defence from disease, the innate immunity, has resulted in some new understanding of the body’s response to HIV virus.

Researchers at NARI, in collaboration with the All India Institute of Medical Sciences (AIIMS), New Delhi and Bangalore-based Jawaharlal Nehru Institute of Advanced Research, were able to identify parts of the HIV antigen that could generate a high degree of immune response.

The findings of three separate studies could be a gamechanger in treatment of HIV-positive people. At NARI, a three-year study identified the immune cells that prevented the HIV virus from replicating. A joint collaboration with other institutes helped researchers identify parts of HIV antigen (epitopes) that could generate a high degree of immune response,explained Dr R Gangakhedkar, Director of NARI.

Share This Article
Share
Related Article

Dr Madhuri Thakar, principal investigator of the NARI study, told The Indian Express that 20 HIV positive participants were enrolled for the study in Pune. However, none of the 20 had taken recourse to anti-retroviral treatment. Some had the disease for 12 years. In other studies, 30 people living with HIV were enrolled by the other institutes.

The study found that the viral load was within limits. There were no any specific symptoms either. This led scientists to explore further and as part of yet an Indo-Australian study, the researchers soon found that these patients had shown a few antibodies (known as antibody dependant cell mediated cytotoxicity: ADCC) that can help kill cells infected with HIV.

The findings of the three-year NARI study, that naturally present (innate) immune cells can help in controlling the HIV virus, is now being explored further, Gangakhedkar said. It is a well-known fact that the immune response in the very early phase of HIV infection might give a clue to identifying a protective and durable immune response.

ART has enhanced the survival rate of HIV-positive individuals immensely. An HIV infected individual’s life can be prolonged by about 45 years if the individual adheres to treatment and has access to different anti-retroviral drugs. Enhancing its coverage is a major challenge. According to National ART consultant Dr B B Rewari, around 8.6 lakh persons are on ART, another 10,000 on second-line ART and the third line of drugs has yet to be rolled out.

India is a decade into free ART. New HIV infections continue to be reported, though the incidence is lesser. A cure for HIV continues to elude scientists. Efforts to develop a vaccine must continue, Gangakhedkar said.

Vaccine research progresses

There is some good news on the AIDS front —Monday, May 18 is AIDS Vaccine Awareness Day— that research on neutralizing antibodies are making progress.

These are proteins developed against HIV antigens and can block HIV activity. A vaccine that provides 70% protection could reduce new infections by 40% in its first decade, and by almost half in 25 years and up to 42 million infections averted by 2070, depending on success of other HIV/AIDS interventions, said Dr Rajat Goyal, Country Director of International AIDS Vaccine Initiative.

For all the latest Pune News, download Indian Express App

  1. J
    jane richard
    Mar 12, 2017 at 12:57 pm
    I am Ella Smith turkey I am grateful to Dr.aze who help me tolt;br/gt;help put a end to my HIV positive [ ve] illness. I saw a blog on thelt;br/gt;Internet on how this Powerful Healer healed someone. As a patient who knowlt;br/gt;this will take my life one day, and I have to live with other relatives andlt;br/gt;friends as well. So I copied Dr. aze, the traditional healer email and contacted him. I would say that he is Godlt;br/gt;sent to me. last week I went to close by the hospital to check my HIVlt;br/gt;status, it was surprising that the lab technician said the test result waslt;br/gt;HIV negative [-ve]. You can contact him at lt;br/gt;telephone number or whatsapp 2349057916457lt;br/gt;my advice is to contact him and tell him about all your health problems.lt;br/gt;thank you very much Dr.azelt;br/gt;doctor can also cure the followinglt;br/gt;1. HIV/AIDSlt;br/gt;2.lt;br/gt;6. chronic pancreaticlt;br/gt;7. Emphysemalt;br/gt;8. COPD (Chronic Obstructive Pulmonarylt;br/gt;Disease)lt;br/gt;9. Asthmalt;br/gt;10.Acute angle-closure Glaucomalt;br/gt;11. Diabetes
    (0)(0)
    Reply
    1. M
      Mary Lender
      Feb 5, 2017 at 10:31 pm
      Attention you all,i don't just know the reason why some people is finding it difficult to believe that there is a cure for HIV, i have been HIV since last three years with my boyfriend but today i am happy that i am HIV_free with herbal medicine of Dr.Omoa the great healer,i was browsing the internet searching for help when i came across a testimony shared by someone on how Dr.Omoa cure his HIV i was so much in need of getting his treatment but after all Dr.Omoa brought a smile to my face with his herbal medicine. i am so much happy today that we have someone like this great healer out there, so my people out there kindly contact this great healer on his email address: please sir keep your good work cause there are people out there who is in need of your healing medicine.once more contact him now: once you get in torch with him tell him that i SANDRA inform you about is ambition work.good he will be willing to help you or contact me on email () call or whatsApp 2348141309378 WARMEST REGARDS
      (0)(0)
      Reply
      1. Sarah Tina
        Feb 7, 2017 at 4:35 am
        I was cured of HIV with the used of natural herbs. My name is Sarah and am from US. I love herbs so much. Most times, injection and drugs are just a waste of time. I was cured 8months ago, i suffered from HIV for 13yrs but with the help of DR. Baba Ogu herbal medicine, i was cured within few weeks of drinking the herbs he sent to me through courier delivery service. This same doctor also cured my Aunt from herpes, as soon as i heard she had herpes, i quickly refer her to Dr. Baba Ogu and she was cured too after drinking his herbs.I have referred more than 15 persons to Dr. Baba Ogu and they were all cured from their various illness. Have you taken herbs before?. You have spent so much money on drugs,injections,surgeries etc and yet you have no good result to show for it. Contact Dr. Baba Ogu now, he is a herbalist doctor, i ured you of a cure if you drink his natural herbs. Dr Baba Ogu have herbs that cures Hiv, Herpes, diabetics, asthma, hepais,HBP, STD, cancer, chronic, etc. He is also a spell caster, he can cast a spell to bring back your EX lover. Contact Dr. Baba Ogu through his Email address on: or WHATSAP/CALL him on 2348137291215. Share the good news to others once you are cured. Thank you.
        (0)(0)
        Reply
        1. J
          JOAN JULLY
          Nov 17, 2016 at 9:43 pm
          Greetings to the general public, i want to tell you about how i was cured of HIV/AIDS disease by a Doctor called Dr ZAKI. I was browsing through the Internet searching for remedy and fast cure on HIV and i saw comment of people talking about how Doctor ZAKI cured them. I Was scared because i never believed in the Internet but i was convince to give him a try because i having no hope of been cured of HIV/AIDS so i decided to contact him with his email that was listed on the comment (dr.zakiherbalhome @gmail) when i contacted him he gave me hope and send a Herbal medicine to me that i took and it seriously worked for me, am a free person now without problem, my HIV result came out negative. I pray for you Dr ZAKI God will give you everlasting life, you shall not die before your time for being a sincere and grate men. Am so happy, you can also contact him if you have any problem Email: dr.zakiherbalhome or Add him up on WhatsAPP 2348148339190
          (0)(0)
          Reply
          1. K
            Kimberly Christopher
            Feb 25, 2016 at 9:39 pm
            Greetings to everyone reading this testimony, I am Kimberly Christopher i am here to testify of a great man who was able to cure me permanently from Hiv Disease just with his herbal medicine,i have been HIV Positive for 5 years before i came across Dr Ijagba Email on the internet on how he has been using his herbal medicine to treat and cure patients from different virus, so i contacted him and i explain to him concerning my problem, i followed up with the instructions he gave me and he urge me to have faith in his words that he was going to restore my health back, after some couple of days Dr Ijagba sent me some medicine which he gave me prescription on how to take for 2 weeks, to make the long story short, I have been confirmed Negative from my recent test in the hospital, just within 2 weeks Dr Ijagba was able to make me healthy and see reasons to live again, though science says there is no cure, i believe God has sent this great man to save people, you can all contact him for his medicine, he has presently been treating diseases like, HERPES,CANCER,BLOOD DISEASE,DIABETES,HIV,TYPHOID, and many others, you can contact this man on ( ) God Bless you sire!
            (0)(0)
            Reply
            1. Load More Comments