Cristiano Ronaldo had limped out of training for three sessions in a row on Tuesday after a clash with goalkeeper Kiko Casilla.
Ronaldo has 16 goals in the Champions League this season and is on track to break his record of 17 set when Real won the competition in 2013-14.
Since Blanc took over as PSG manager from Carlo Ancelotti, he has guided the club to three successive French titles, but suffered in Europe.
City qualified for the Champions League semifinals for the first time with Kevin de Bruyne securing a hard-fought 1-0 victory versus PSG.
Real have a reputation for great fightbacks but they hadn’t overturned a first-leg deficit in Europe since 2002 against Bayern Munich.
Benfica’s Gaitan floated a late free kick into the area and the Stadium of Light erupted as Jonas outjumped the defence for the winner.
The Portugal international was asked if Barca’s attacking trio had the edge over Real’s strikers because they get on so well together.
Praising his players for being tactically organised, the Dutchman rued Chelsea’s lacklustre play on counter attacks.
Uruguayan Edinson Cavani who has scored only once in Ligue 1 this year scored the winner four minutes after coming on as a substitute.
FC Porto, the club Jose Mourinho led to the Champions League title in 2004, scored in each half through Andre Andre and Maicon.
Barcelona were handed a favorable start to its title defence with Bayer Leverkusen, Roma and BATE Borisov.
Both teams played outstanding, attacking football in one of the greatest European finals.
Just days after the Blatter fiasco, the game turns its attention to the Champions League final in Berlin.
Juventus will face Barcelona in the final, which will be played in Berlin on June 6.
Defensive lapses have cost Madrid in recent weeks as they have conceded twice in four of their last five matches.