Barcelona forward Luis Suarez has been ruled out for 15 days due to hamstring injury.
Detentions are part of a money laundering investigation related to buying television rights for past matches of Brazil team.
James Rodriguez and Alvaro Morata scored a brace each to give Real four goals advantage in the first half.
UEFA considers it a political symbol and fined Barcelona 40,000 euros after it was flown during group game against Bayer Leverkusen last September.
Barcelona title run suffered another setback after they lost 2-1 to Valencia; currently at top with 76 points, level with Atletico Madrid.
Barcelona suffer a 2-0 defeat to Atletico Madrid to lose 3-2 on aggregate and crash out of the UEFA Champions League.
Relevant Sports’ chairman Charlie Stillitano met representatives of top European clubs to discuss changing the Champions League.
Defending champions Barcelona, enter into the Champions League quarterfinals for a ninth consecutive season with a 5-1 victory on aggregate over Arsenal.
Barcelona leads Arsenal 2-0 heading into the second leg in the Champions League on March 16.
Cristiano Ronaldo fluffed his best chance to increase his lead over Luis Suarez in the fight to be La Liga’s top scorer.
Barcelona come from behind with a goal each from Lionel Messi and Gerard Pique to beat Sevilla 2-1.
Messi, Suarez, and a tale of large-heartedness or cold calculation.
Barcelona star Lionel Messi scored an incredible goal in training on Monday much to everyone’s surprise and deservedly taking a bow later.
Lionel Messi stunned everyone by passing a spot kick to Luis Suarez, who raced into the box and scored his hat-trick.
Barcelona reached to 57 points after the 6-1 win over Celta Vigo and three points clear of Atletico Madrid.